• The anticoagulant action of drugs such as bishydroxycoumarin can be corrected, when necessary, by administration of vitamin K1. Its effectiveness for this purpose was observed in 20 patients who had been receiving anticoagulants as prophylaxis against thromboembolic complications of various diseases, especially acute myocardial infarction. Prothrombin times were determined at stated intervals before and after intramuscular injection of vitamin K1 and again after intravenous injection. The intramuscular injections had unpredictable effects, and the average change in prothrombin time did not differ significantly from zero. The intravenous injections, however, generally had the desired effect of shortening the prothrombin time. The shortening amounted to about 10 seconds on the average and was most marked from 8 to 24 hours after the injection of the vitamin.
Shoshkes M, Perelman AJ. VITAMIN K1 IN TREATMENT OF BISHYDROXYCOUMARIN— INDUCED HYPOPROTHROMBINEMIACOMPARISON OF INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION. JAMA. 1956;161(12):1145–1147. doi:10.1001/jama.1956.02970120027008
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