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September 21, 1957


JAMA. 1957;165(3):278. doi:10.1001/jama.1957.02980210074020

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To the Editor:—  Previous experiences with the intracutaneous method of immunization introduced originally by me for typhoid vaccine and later applied to other antigens (J. A. M. A.164:1626 [Aug. 3] 1957) make it quite natural for the question to be raised as to whether this method could be applied in the immunization of individuals with the Asian influenza virus vaccine. I have been asked this question by several physicians with the objectives in mind of conserving the vaccine supply and of minimizing reactions. Previous experiments with vaccines prepared from strains of influenza virus other than the Asian have shown that an intracutaneous injection of 0.1 ml. of such a vaccine induces a degree of immunity in terms of antiviral antibody comparable to that provided by a subcutaneous injection of 1.0 ml.Because the Asian strain is new to the United States, sufficient time has not elapsed to determine

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