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Article
September 28, 1957

AZACYCLONOL (FRENQUEL) HYDROCHLORIDE IN THE TREATMENT OF CHRONIC SCHIZOPHRENIAA DOUBLE-BLIND, CONTROLLED STUDY

JAMA. 1957;165(4):333-335. doi:10.1001/jama.1957.02980220017005
Abstract

Therapeutic changes most frequently observed in patients taking azacyclonol hydrochloride were disappearance of hallucinations and lessening or disappearance of delusions, false ideas of reference, assaultiveness, agitation, and seclusiveness. Azacyclonol can be said to have a statistically significant effect in that 61 patients improved after drug therapy as opposed to 28 after use of the placebo. There were no untoward reactions attributable to the use of azacyclonol.

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