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Article
October 5, 1957

CHANGING FORMS AND CAUSES OF PULMONARY INSUFFICIENCY IN PRESENT ERA OF MEDICINE

JAMA. 1957;165(5):431-436. doi:10.1001/jama.1957.02980230001001
Abstract

The incidence of insidious protracted development of pulmonary insufficiency is increasing, due to the delayed effects of pulmonary infections attenuated by chemotherapy, and to the cumulative effects of inhaled air pollutants. We are not dealing with complicating infections but rather, the signs and symptoms observed are the manifestations of pulmonary insufficiency itself. Pulmonary insufficiency implies disturbances in the autonomic functions of the structures at the bronchioloalveolar junctions. The exact nature of these functions is not known, but there is ample evidence that they are essential to normal distribution of ventilation and circulation throughout all parts of the lungs. The disturbance of this critical function implicated in pulmonary insufficiency may best be designated by the least prejudicating term of "bronchioloalveolar dysfunction."

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