The vasod[ill]ng action of piperoxan hydrochloride has an important application in the treatment of the local ischemia that results when extravasations of levarterenol occur during intravenous injections. The ischemia is marked by coldness, pallor, and numbness and has sometimes gone on to necrosis. Three case histories are given to illustrate the prompt relief of the ischemia by piperoxan hydrochloride. The latter is injected subcutaneously in multiple punctures about the affected vein in the form of a solution containing 5 mg. in 20 cc. of sterile saline solution, and the amount needed varies from 20 to 30 cc. A satisfactory vasodilation occurs within one minute and is manifested by the return of a healthy pink color to the ischemic area.
Pelner L. TREATMENT OF LOCAL ISCHEMIA DUE TO LEVARTERENOL (LEVOPHED) LEAKAGE WITH PIPEROXAN. JAMA. 1957;165(5):444–447. doi:10.1001/jama.1957.02980230014004
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