The most common pathogenic factor in postnecrotic cirrhosis is an illness which resembles in all respects acute infectious hepatitis. How often cirrhosis follows hepatitis is not known, but there are patients whose illness progresses to cirrhosis while they are under observation. Furthermore, patients with at least one type of cirrhosis often give a history of a preceding hepatitis. The pathological process of postnecrotic cirrhosis consists of necrosis of liver cells, regeneration of hepatic tissue, and the formation of large bands of connective tissue which course irregularly through the liver. The factors which determine whether cirrhosis occurs following acute infectious hepatitis, as well as the variety of cirrhosis that develops, are all still unknown.
Ratnoff OD. POSTHEPATITIC CIRRHOSIS. JAMA. 1957;165(9):1096–1098. doi:10.1001/jama.1957.02980270006002
Customize your JAMA Network experience by selecting one or more topics from the list below.