Three two-year periods (1938-1939, 1948-1949, and 1954-1955) have been compared as to the incidence of disseminated lupus erythematosus in a Swedish city. The case records of all patients with neuritis, fever of unknown origin, sepsis, uncertain diagnosis, and diseases of the heart, blood vessels, joints, and skin were reviewed. The suspected cases so found were all followed up and the diagnosis was verified in 24 cases by data from reexamination, records of later hospitalizations, or autopsy. The number of cases (18) during the third period was six times as great as that during the first (3) and the second (3) periods. This is not accounted for by the increases in the population of the city or by any change in diagnostic criteria. The authors give reasons for concluding that there has been a genuine increase in the incidence of disseminated lupus erythematosus.
Svanborg A, Sölvell L. INCIDENCE OF DISSEMINATED LUPUS ERYTHEMATOSUSFOLLOW-UP STUDIES INDICATING INCREASED FREQUENCY. JAMA. 1957;165(9):1126–1128. doi:10.1001/jama.1957.02980270036008
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