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November 9, 1957


JAMA. 1957;165(10):1227-1230. doi:10.1001/jama.1957.02980280001001

Bronchitis proper is a distinct entity from emphysema. Causal relationship between them is exceptional rather than usual. Severe bronchitis and diffuse pulmonary emphysema are to a large extent incompatible. Simple chronic bronchitis is a common trivial disease of the central tracheobronchial tree. Emphysema usually associated with bronchiolitis results from impaired function of the finer structures of the lungs. This constitutes an ominous clinical picture for the patient and now appears to be rising in incidence. Complete understanding of emphysema with bronchiolitis awaits further investigation of the mechanical, nervous, and circulatory factors involved in the functions of the bronchioalveolar structures.