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Article
November 9, 1957

RAYNAUD'S DISEASE IN PRIMARY PULMONARY HYPERTENSION

JAMA. 1957;165(10):1245-1248. doi:10.1001/jama.1957.02980280019006
Abstract

Vasoconstrictor spasm involving the extremities and causing severe local ischemia was observed in three patients. In each there was also evidence of pulmonary hypertension which was primary in the sense that no significant parenchymal lung disease or congenital cardiac defect could be demonstrated. The coincidence of the peripheral vascular spasm with pulmonary hypertension in these patients suggests the possibility that the latter condition might likewise be a spastic vasomotor process involving the pulmonary arterioles.

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