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Article
November 23, 1957

DIAGNOSTIC PROCEDURES FOR PHEOCHROMOCYTOMATECHNIQUE OF ASSAY OF URINE IN RAT AND DEMONSTRATION OF PIPEROXAN HYDROCHLORIDE— ANTIDIURESIS DURING NORMOTENSIVE PHASE

JAMA. 1957;165(12):1555-1557. doi:10.1001/jama.1957.72980300001009
Abstract

This report demonstrates the usefulness of two diagnostic procedures in the normotensive phase of pheochromocytoma with paroxysmal hypertension. One of these—approximate assay of the pressor activity of the urine in the rat—has not been described as such, although similar assays in a cat that has been injected with ergotamine have been shown to be of diagnostic value.1 The other procedure is the demonstration of an antidiuretic effect of piperoxan hydrochloride during the normotensive phase of the disease. This effect of piperoxan had previously been observed only in patients with hypertension due to pheochromocytoma and in normal subjects given pressor doses of epinephrine and arterenol. The question whether the decreased arterial pressure would affect the antidiuresis was unanswered, and we doubted that the test would be useful in the normotensive phase of pheochromocytoma.2

Report of a Case  A 22-year-old man had been medically discharged from the U. S. Army

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