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December 7, 1957


JAMA. 1957;165(14):1860-1861. doi:10.1001/jama.1957.02980320090022

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To the Editor:—  For the past nine weeks our group has been conducting extensive studies on the immunization of children, young and middle-aged adults, and older individuals against Asian influenza with use of monovalent vaccine obtained from three pharmaceutical houses. One lot of vaccine (A-1) contained 100 CCA units per milliliter. All the rest contained 200 CCA units. In all, more than 1,000 individuals were inoculated. These were divided into groups according to the following inoculation programs: (1) single subcutaneous injection of 1 ml. for adults and 0.5 ml. for children; (2) single intradermal injection of 0.1 ml.; (3) intradermal injection of 0.1 ml. into two sites; (4) primary inoculation of 1 ml. subcutaneously or 0.1 ml. intradermally followed by a second intradermal injection of 0.1 ml. one to six weeks later; (5) single injection of 0.1 ml. deliberately given subcutaneously; and (6) intradermal injection of 0.1 ml. of polyvalent

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