When treating allergy with corticotropin and the adrenal steroids, it is necessary to realize how little we know about them and the influence they have upon allergic disease. They seem to have no appreciable effect at the antigen-antibody level of activity. It is also necessary to understand the dangers inherent in the drugs themselves. Symptoms of infection can be camouflaged and the infection itself can become uncontrolled. A recent study indicates that protection by tetanus antitoxin is greatly reduced when steroids are used and that this effect is due to the enhancement by steroids of toxin potency. One is justified in using corticotropin or the adrenal steroids in that small group of patients who either do not respond adequately to time-honored procedures or who develop isolated and refractory episodes of their disease.
Bookman R. STATUS OF CORTICOTROPIN AND THE STEROID HORMONES IN THERAPY OF ALLERGIC DISEASE. JAMA. 1957;165(15):1950–1953. doi:10.1001/jama.1957.02980330052012
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