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December 14, 1957


JAMA. 1957;165(15):1955-1956. doi:10.1001/jama.1957.72980330003013a

Uniocular granulomatous conjunctivitis with preauricular adenopathy (Parinaud's syndrome) is one manifestation of cat-scratch disease,1 differing from other forms in that the conjunctiva is the primary portal of entry of the infective agent. A positive skin test made with an antigen prepared from purulent glandular material or gland tissue from a patient with the disease is specific and essential for diagnosis.2

It is well known that Parinaud's syndrome may be due to various causes3 and that in many cases subjected to the fullest investigation the etiology remains obscure. The three most frequent causes are leptotrichosis,4 tularemia, and tuberculosis. Other known causes are syphilis, lymphogranuloma venereum, sarcoidosis, glanders, Newcastle virus infection, listeriosis,5 and other mycotic infections such as sporotrichosis and rhinosporidiosis.

Parinaud's syndrome, as a manifestation of catscratch disease, has been reported by many in France since 1950.6 In 1953 Van Veelen and Stibbe in Holland