The nonsurgical treatment of regional enteritis is most applicable to three types of patients: those with mild disease without evidence of obstruction or perforation, those with disease too severe for resection, and those in whom recurrences and repeated resections have reduced the functioning small intestine below the minimum for safety. Medication may include antibiotics, tranquilizers, salicylazosulfapyridine (Azulfidine), vitamin B complex, vitamin K, and calcium. Steroids should rarely be given and only after careful consideration of the individual case. Transfusions have an inestimable value to patients anemic from hemorrhages and malnutrition. Changes of diet, such as the omission of milk, have occasionally restored a patient to health. Roentgenotherapy has proved to be the most valuable adjunct to treatment. Its use is illustrated by the history of a patient in whom a vaginal fistula had developed and the related complications were too extensive for surgery; marked amelioration followed roentgenotherapy and the administration of salicylazosulfapyridine, high-protein diet, and extra vitamins.
Bargen JA. NONSURGICAL MANAGEMENT OF REGIONAL ENTERITIS. JAMA. 1957;165(16):2045–2047. doi:10.1001/jama.1957.02980340011003
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