Dithiazanine was given by mouth to patients with various helminthiases. Trichuriasis in 164 patients was treated with doses of 200 mg. thrice daily; this dosage, continued for five days, cured 97% of the patients. Ascariasis was treated in 42 persons with up to 600 mg. daily in divided doses. There was a 97% reduction in the egg-count of these patients, and 28 of them showed complete elimination of the infection. Strongyloidiasis was eliminated in 16 out of a group of 18 patients treated for 5 to 21 days. Enterobiasis was treated in 35 boys under conditions showing that 100 mg. of dithiazanine thrice daily for five days sufficed for cure in all cases. Hookworm infection was found present in 39 of the preceding groups of patients being treated for other helminthiases; the treatment incidentally caused reductions of the hookworm egg counts. Similar reduction was observed in a separate group of eight patients with hookworm, but better results were obtained by giving subcurative doses of tetrachloroethylene with the dithiazanine. The sideeffects of the drug were minimal, and its usefulness for the mass therapy of trichuriasis was demonstrated.
Swartzwelder JC, Frye WW, Muhleisen JP, et al. DITHIAZANINE, AN EFFECTIVE BROAD-SPECTRUM ANTHELMINTIC: RESULTS OF THERAPY OF TRICHURIASIS, STRONGYLOIDIASIS, ENTEROBIASIS, ASCARIASIS, AND HOOKWORM INFECTION. JAMA. 1957;165(16):2063–2067. doi:10.1001/jama.1957.02980340029008
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