Three patients developed severe, immediate allergic reactions after the injection of an immunizing agent. Each of the three patients gave a positive direct or passive transfer reaction to silk extract. This proved that the patients were allergic to silk and that it was this antigen, present as a contaminant in the biological products, which produced the allergic reactions in these patients. It is apparent that sufficient amounts of silk antigen become incorporated into the biological product as a result of filtration through silk membranes to be antigenically significant when given to a highly allergic individual.
Brown SF, Coleman M. SEVERE IMMEDIATE REACTIONS TO BIOLOGICALS CAUSED BY SILK ALLERGY. JAMA. 1957;165(17):2178–2180. doi:10.1001/jama.1957.02980350036008
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