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August 25, 1956


JAMA. 1956;161(17):1699-1700. doi:10.1001/jama.1956.02970170095020

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To the Editor:—  Dr. Armand J. Quick has kindly sent us a transcript of his comments on our recent article "Effect of Bishydroxycoumarin (Dicumarol) on Clotting Time of Whole Blood" (J. A. M. A.161:806 [June 30] 1956). We fully agree that the commonly used clotting time techniques have no place in the control of Dicumarol therapy. In our study, we used a new method, which is highly reproducible and is devoid of the common sources of error inherent in previous tests. Unfortunately, Dr. Quick is unacquainted with our method, and his comments are directed at techniques of notorious inaccuracy. Since we completed our Dicumarol study, we have continued our work. We have now observed 310 patients, including 46 on long-term anticoagulant therapy, under treatment with Sintrom, Tromexan, and Indon (phenindione), as well as with Dicumarol, for a total of 13,500 treatment-days. Our therapy was directed entirely by our

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