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Article
January 4, 1958

UNILATERAL RENAL DISEASE AND HYPERTENSION: REPORT OF THREE SUCCESSFULLY TREATED CASES

Author Affiliations

Salt Lake City

From the Department of Medicine, University of Utah College of Medicine, and the Veterans Administration Hospital.

JAMA. 1958;166(1):18-22. doi:10.1001/jama.1958.02990010020005
Abstract

At the present time the bulk of evidence seems to implicate pyelonephritis and various vascular lesions as the two main causes of renal hypertension. The theory is that an ischemic kidney elaborates a proteolytic enzyme (renin) which combines with a plasma globulin to produce an active pressor polypeptide which elevates the blood pressure. The manifestations of unilateral disease vary, but suspicion should be aroused when the history includes recent trauma to the abdomen or flank, abdominal or flank pain mimicking abdominal disease, a known source of emboli, and past pyelonephritis. Ureteral catheterization for measurement of sodium and water excretion will aid in the detection of an increased number of such

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