It has been reported1 that during the midportion of the menstrual cycle a decrease in the concentration of reducing substances is present in cervical secretions. This observation suggested to one of us (C. H. B.) that significant chemical alterations in cervical secretions might take place at the time of ovulation. The variation in reducing substances might then result from a hydrolytic splitting of cervical mucus or glycogen, and glucose might be present in cervical secretions as a result of this hydrolysis. The presence of glucose could then be determined by the use of Tes-Tape.
The basis for the use of Tes-Tape as a test for glucose is the observation of Keston2 on the simultaneous use of two enzyme systems for the detection of glucose. Glucose oxidase is a specific enzyme that catalyzes the oxidation of glucose and oxygen into gluconic acid and hydrogen peroxide. Hydrogen peroxide and orthotolidine
Birnberg CH, Kurzrok R, Laufer A. SIMPLE TEST FOR DETERMINING OVULATION TIME. JAMA. 1958;166(10):1174–1175. doi:10.1001/jama.1958.62990100002010a
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