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March 15, 1958


Author Affiliations

Henry Avenue and Abbottsford Road Philadelphia 19.

JAMA. 1958;166(11):1361. doi:10.1001/jama.1958.02990110097021

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To the Editor:—  In the Correspondence section of The Journal on Nov. 30, 1957, page 1739, appeared a letter from Dr. Ernest B. Zeisler of Chicago in which he offered criticism of my paper on "Treatment of Chronic Schizophrenia" which appeared in The Journal on Sept. 28, 1957. He noted that the fourfold table was not included in the paper, disagreed with my statement about the relationship of p values and establishment of a hypothesis, and quotes an example from a game of bridge to elucidate the problem for nonmathematical readers.I must agree that my statement "a p value of less than 0.05 is adequate to establish a hypothesis" is incorrect. However, Dr. Zeisler's further comment that the p value cannot measure the probability that a hypothesis is correct and his discussion of the relationship of the p value and chi-square is erroneous. In my paper, the p value

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