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March 22, 1958

Brain Tumors: Their Biology and Pathology

JAMA. 1958;166(12):1534. doi:10.1001/jama.1958.02990120126029

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The development of our knowledge of the biological behavior of brain tumors, as deduced from their pathological appearances, was one of the chief contributions from the clinic of the late Harvey Cushing. The gliomas were studied by Percival Bailey and glioma cells, classified according to cell types, were compared with the cells of normal brain tissue. To this basic study Bailey and Cushing added a survey of the clinical course and prognosis of brain tumors, thus bringing order out of the previous chaos. The different forms and types, moreover, were correlated with a particular survival period, and note was made of tumors showing a preference for certain age groups and various sites of origin. The "American classification" of Bailey and Cushing (1926) was accepted throughout the world and, with a few modifications, is the basis for the current concept of brain tumors. This classification has been somewhat simplified in recent

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