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The first section of this book deals with the clotting defect in hemophilia. The antihemophilic factor, the isolation and assay of antihemophilic globulin, and standardization of so-called antihemophilic fractions are discussed by American, Swiss, and French authors respectively. Then follow four papers on inhibitors and hemophilia, specifically on the role of certain plasma factors and anticoagulants. Contrary to claims made previously, antibodies against clotting factors could not be demonstrated by Pennalver and associates. Deficiency of hemostasis and of platelets are the subject of the two concluding papers of section 1. Parahemophilia, proconvertin deficiency, plasma thromboplastin component deficiency, plasma thromboplastin antecedent deficiency, and the so-called Hageman trait are discussed in section 2. Five papers deal with genetic and marriage problems, three with problems of diagnosis, and four with management in sections 3, 4, and 5. A beautifully illustrated paper on the pathology of hemarthrosis in hemophiliac dogs and papers on bone
Hemophilia and Hemophilioid Diseases: International Symposium. JAMA. 1958;166(13):1656–1657. doi:10.1001/jama.1958.02990130116028
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