The effectiveness of chlorpromazine was compared with that of insulin coma in 60 patients referred for insulin coma therapy. Onehalf the group, selected on a random basisreceived chlorpromazine by mouth for at least three months in doses adjusted so as to fall just short of toxicity in the individual patient; this dosage varied from 300 mg. to 2,000 mg. daily, with a median of 800 mg. The insulin coma was induced by a standard technique 50 times in each patient. Although many minor differences were noted in comparing the effects of these two methods of treatment, the ultimate results at the time of discharge were essentially the same for the two groups of patients. Neither treatment affected the basic schizophrenic process, but chlorpromazine had the advantage of being safer, easier to administer, and better suited to long-term management.
Fink M, Shaw R, Gross GE, Coleman FS. COMPARATIVE STUDY OF CHLORPROMAZINE AND INSULIN COMA IN THERAPY OF PSYCHOSIS. JAMA. 1958;166(15):1846–1850. doi:10.1001/jama.1958.02990150042009
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