The responses of 100 chronic alcoholic patients with acute complications were studied with respect to azacyclonol hydrochloride, a drug with marked antihallucinatory effect. It was given by mouth, generally in doses of one 100-mg. tablet four times a day, in addition to the medication usually given to patients who are psychologically and biologically in extremis. Of the 75 who had hallucinations, 60 recovered quickly and 8 were improved. The effects are illustrated by two case histories. By treating this group of patients successfully while they were in extreme situations, rapport and confidence were established which formed the basis for more definitive treatment of the patient's total problem. Hospitalization might have been useful in many cases, but it is believed that azacyclonol was of considerable help in treating these people at the outpatient level.
Travis JC. TREATMENT OF THE ACUTE COMPLICATIONS OF CHRONIC ALCOHOLISM: USE OF AZACYCLONOL (FRENQUEL) HYDROCHLORIDE IN ONE HUNDRED CONSECUTIVE CASES. JAMA. 1958;167(2):156–159. doi:10.1001/jama.1958.02990190010002
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