The ability of methocarbamol to relax spastic muscles was noted incidentally to other studies, but was found to merit special investigation. The effects here reported were obtained in 58 patients with acute orthopedic conditions (especially herniated lumbar and cervical disks) causing painful muscular spasms, 7 patients with chronic conditions, and 18 patients recovering from orthopedic surgery. The average oral dose of methocarbamol was 6 Gm. per day in divided doses, using 500-mg. scored tablets. The relief from pain was often prompt and striking. The resultant facilitation of treatment and hastening of recovery is exemplified in four case histories. Side-effects were minor, but occasionally made it necessary to reduce or interrupt medication. Methocarbamol was particularly useful in such procedures as reducing dislocated shoulders without anesthesia and manipulating spastic feet.
Forsyth HF. METHOCARBAMOL (ROBAXIN) IN ORTHOPEDIC CONDITIONS: PRELIMINARY REPORT OF ONE HUNDRED CASES. JAMA. 1958;167(2):163–168. doi:10.1001/jama.1958.02990190017004
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