This study was undertaken in an effort to establish a safe method of rapidly digitalizing ambulatory patients, preferably in one clinic visit, by means of the combined administration of a parenterally and an orally given digitalis preparation and also to evaluate the feasibility of the intramuscular route of administration of deslanoside (desacetyllanatoside C, lanatoside D). It was prompted by the necessity of treating a large number of patients in an active cardiac clinic where available personnel was minimal and patient attendance irregular.
Material and Methods
In order to provide a means of measuring the effect of the drugs, selection was limited to patients with atrial fibrillation. The study includes 16 patients, 3 of whom received two trials with deslanoside. All patients had well-documented heart disease. Each was observed for a period of four weeks before the study was begun, during which time no digitalis preparations of any kind were used.
Hellman E, Port M. RAPID DIGITALIZATION OF AMBULATORY PATIENTS WITH ATRIAL FIBRILLATION: USE OF INTRAMUSCULARLY GIVEN DESLANOSIDE FOLLOWED BY ORALLY GIVEN ACETYLDIGITOXIN. JAMA. 1958;167(2):215–216. doi:10.1001/jama.1958.72990190002015a
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