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May 24, 1958


Author Affiliations

University of Louisville Louisville 2, Kentucky.

JAMA. 1958;167(4):499. doi:10.1001/jama.1958.02990210085016

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To the Editor:—  In view of the possible encouragement to practitioners to administer estrogens to tall peripubescent girls, there are some pertinent points in the interesting article of Dr. S. Charles Freed in The Journal, March 15, 1958, page 1322, wherein he describes the results of such therapy on two patients.First, Dr. Freed does not state (a) the possible measurement errors of incremental growth in height. In measuring increments in six-month periods where one is dealing with such gains as 4.0 cm. to 0.32 cm., for instance, measurement error can be a very vital factor. He does not state (b) how he predicted the amount the patient would grow in height before maturity. Bayley and Pinneau (J. Pediat.40:423-441 [April] 1952) have shown the potential errors in such prediction before the age of 12 years and have suggested that supplementary tables are needed for children advanced or retarded

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