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Article
June 21, 1958

ELECTROENCEPHALOGRAPHIC STUDY OF PERSONS BEFORE AND AFTER POLIOMYELITIS VACCINATION

JAMA. 1958;167(8):929-931. doi:10.1001/jama.1958.02990250001001
Abstract

Electroencephalograms were obtained from 852 normal subjects before and after the first, second, and third inoculations with Salk vaccine for poliomyelitis. The series included infants, children, adolescents, and adults. No electroencephalographic abnormalities were induced by the vaccination in initially normal people. The possibility that vaccination might cause detectable injury in brains already handicapped by previous disease or injury was also investigated. A group of 106 persons with brain disorders, including 44 with epilepsy, were studied electroencephalographically. Again no evidence of harm from the vaccination was obtained. The vaccines used in this study were commercial preparations from two drug companies, and the evidence showed that these preparations could be given safely to patients with or without manifestations of preexisting cerebral disease.

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