Sixty patients with psoriasis were treated with triamcinolone, a corticosteroid, in doses of 12 to 16 mg. daily by mouth. In 36 of the patients the response was prompt and unquestionable; within a week, the scaling and erythema diminished significantly, and within two to four weeks of continued adequate dosage the psoriasis was, in some patients, completely erased. Upon cessation of treatment or reduction of dosage, however, the lesions regularly returned. The remaining 24 patients failed to show any response. A wide variety of reversible side-effects were observed. Some were favorable, such as the stimulation of hair-growth in alopecia areata, and many were unfavorable, such as flushing, hyperhidrosis, facial hirsutism, and facial contour changes. Triamcinolone was found to be highly antiallergic, antirheumatic, and antiinflammatory, and therefore useful in a variety of dermatitides; its use in psoriasis should probably be limited to acute extending cases not controllable by other means or to very extensive and severe chronic forms.
Shelley WB, Harun JS, Pillsbury DM. THE TREATMENT OF PSORIASIS AND OTHER DERMATOSES WITH TRIAMCINOLONE (ARISTOCORT). JAMA. 1958;167(8):959–964. doi:10.1001/jama.1958.02990250031006
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