Since October, 1932, 3,120 patients with a positive diagnosis of rheumatoid arthritis have been studied. Since 1940, gold salts have been given to all patients with reversible rheumatoid arthritis who were in good health otherwise. The gold salt was given intramuscularly at weekly intervals, the initial dose being 10 mg., then 20 mg., and then 40 mg. weekly. If no signs of sensitivity appeared, treatment was continued until 500 mg. had been given. Use of gold salts affords patients 20% better chance of complete recovery or of major improvement. Severe reaction to gold occurs in a very small percentage of patients.
Lockie LM, Norcross BM, Riordan DJ. GOLD IN THE TREATMENT OF RHEUMATOID ARTHRITIS. JAMA. 1958;167(10):1204–1207. doi:10.1001/jama.1958.02990270010003
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