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To the Editor:—
In The Journal of February 22, page 881, we were pleased to see that another physician, Dr. Austin R. Stough, has been studying the possibile habituating properties of meprobamate. We were sorry to see that no true controls were used, although placebos were utilized. It seems that the observations of the patients were not conducted by a "blind" observer and that no truly objective evaluation of the patients was made before, during, and after the study, except for physiological measurements. Dr. Stough's paper and conclusions are important, but there are a few points with which we would like to take issue.In discussing possible habituation to meprobamate, Dr. Stough states that tolerance is absent or minor in habituation and progressively increases in addiction. He states that "no true habituations" to meprobamate developed. It seems to us that he did demonstrate the development of tolerance in his patients.
John A. Ewing, Thomas M. Haizlip. DRUG HABITUATION. JAMA. 1958;167(13):1666–1667. doi:10.1001/jama.1958.02990300092022