In a previous issue of The Journal1 we said that heretofore there were two indications for the treponema pallidum immobilization (TPI) test but that to these should be added a third. We recommended this test in the following situations: (1) to help distinguish between the biologically falsepositive and true-positive blood test for syphilis; (2) to assist in establishing a diagnosis of syphilis in patients who have clinical evidence of the disease, particularly in late syphilis, but who have negative blood and spinal fluid serologic tests; and (3) to assist in the diagnosis of syphilis in a patient with epidemiologic evidence of the disease but with negative clinical and serologic findings.
As illustrative of the third indication, a case was presented wherein an 8-year-old boy, examined by us in 1955 because of a positive reaction to the Hinton test, proved on clinical examination to have congenital syphilis. However, his mother
Fiumara NJ, Hill W. NEGATIVE REAGIN TESTS IN MARITAL PARTNER OF PATIENT WITH SECONDARY SYPHILIS: THIRD INDICATION FOR TREPONEMA PALLIDUM IMMOBILIZATION TEST. JAMA. 1958;167(17):2067–2069. doi:10.1001/jama.1958.72990340003006a
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