This report represents the findings in four patients with marked uterine procidentia who were treated nonsurgically with rather dramatic results: the reduction of uterine hernia after the oral and parenteral administration of estrogenic hormones.
Although uterine prolapse has been described in the newborn infant and in the nulliparous woman, it is most generally observed in the older multipara whose tissues have shown signs of loss of resiliency, as has been observed by Wilson.1 Mengert2 has rather conclusively pointed out anatomically that the bifid cardinal ligaments are the sole means of support in maintaining the uterus within its normal gynecologic confines. He has shown experimentally that only when the cardinal ligaments were cut, regardless of what other structures were intact, was there any appreciable descensus. The etiological factor, or factors, causing a change in the normal supporting mechanism of the cardinal ligaments is at present unknown, although many have
Anderson HE. CLINICAL USE OF ESTROGEN IN UTERINE PROLAPSE. JAMA. 1958;168(2):173–174. doi:10.1001/jama.1958.63000020001007
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