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November 8, 1958


Author Affiliations

Kansas City, Kan.

From the Department of Medicine and Microbiology, University of Kansas School of Medicine.

JAMA. 1958;168(10):1346-1351. doi:10.1001/jama.1958.63000100001010

The treatment of endocarditis caused by Staphylococcus (Micrococcus) pyogenes var. aureus has become a challenging problem; therefore, two patients successfully treated with a new antibiotic agent, ristocetin, are reported on here. In these two patients, the infections were acquired in hospitals and, as might be expected, the staphylococci were resistant to penicillin. Each was critically ill when therapy was started, and the use of ristocetin was associated with prompt clinical improvement and eventual bacteriological cure.

Thrombophlebitis of severe degree developed in both patients and complicated administration of the antibiotic, and severe leukopenia occurred approximately two weeks after the onset of therapy in both patients. These complications cleared after completion of therapy.

Report of Cases 

Case 1.—  A 32-year-old woman was admitted to the University of Kansas Medical Center on Oct. 9, 1957. She first noted the onset of chills and fever during the afternoon of Sept. 21. The next day,