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November 29, 1958

Clinical Enzymology

JAMA. 1958;168(13):1831. doi:10.1001/jama.1958.03000130097033

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This volume contains a discussion on enzymes used in clinical medicine—largely on those administered parentally, but also a limited discussion on those used diagnostically. Its seven chapters are written by six authors. The subjects covered include protein biology, the chemistry and biochemistry of enzymes used clinically and their parental use in medicine, enzymes used in diagnosis, and polymerases. Much of the chapter on protein biology deals with enzymes. Their mode of action and the effect of concentration on their action as well as the antigenicity of enzyme preparation and the cell permeability to enzymes are discussed. The three chapters on the chemical, biochemical, and medicinal aspects of clinically used enzymes deal chiefly with trypsin, chymotrypsin, ribonuclease, hyaluronidase, cholinesterase, streptokinase, and desoxyribonuclease. The enzymes used for diagnostic purposes include the phosphatases, amylase, trypsin, lysozyme, hyaluronidase and antihyaluronidase, uropepsin, cholinesterase, and transaminase. This volume is somewhat uneven in that the chapters contributed

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