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December 20, 1958


Author Affiliations


From the departments of medicine, Harvard Medical School and the Peter Bent Brigham Hospital (Drs. Thorn, Renold, and Nelson) and investigator, Howard Hughes Medical Institute (Dr. Nelson).

JAMA. 1958;168(16):2130-2137. doi:10.1001/jama.1958.63000160007011

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The availability of precise diagnostic techniques and the synthesis of several important adrenal cortical steroids provide the practicing physician with an unusual opportunity for establishing a correct diagnosis and initiating appropriate therapy in patients with abnormalities of adrenal cortical function. The ever-widening horizon of the nonspecific use of adrenal steroid therapy and the exploration of the beneficial effect of hypophysectomy and adrenalectomy have increased greatly the numbers of patients with evidence of altered adrenal cortical function. The development of accurate and clinically applicable measurements of catechol amine levels in blood and urine has enhanced the accuracy with which pheochromocytoma may be detected and has provided a new and important screening technique which should be applied to all patients with hypertension of undetermined origin.

Hormone Preparations  The structural formulas of the adrenal steroid compounds are represented in figure 1.

Corticotropin.—  Corticotropin ( Acth, Lyophilized Acthar, Corticotropin, Lyophilized Corticotropin), also known as

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