The treatment and prognosis of alcoholic cirrhosis of the liver must take into account the possibility of coexistent disease in other organs. The frequency of extrahepatic disease was studied in the histories of 201 patients in whom the diagnosis had been established by the anamnesis of chronic alcoholism and (in 55 cases) by examination of tissues. The diseases most frequently found were chronic lung disease, diabetes mellitus, peptic ulcer, and cholelithiasis (32, 19, 17, and 17 cases respectively). The symptoms associated with cirrhosis in the 201 patients were spider angioma, ascites, palpable spleen, and hematemesis in 55%, 52%, 27%, and 15% respectively. Although there is disagreement as to the significance of some of these associations, they suggest that the patient with alcoholic cirrhosis has an increased tendency to develop extrahepatic disease.
Pollard HM, Gracie WA, Sisson JC. EXTRAHEPATIC COMPLICATIONS ASSOCIATED WITH CIRRHOSIS OF THE LIVER. JAMA. 1959;169(4):318–321. doi:10.1001/jama.1959.03000210012003
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