Certain biliary calculi become radiographically opaque after prolonged exposure to cholecystographic contrast mediums. The condition of prolonged exposure is fulfilled by the four-day iopanoic acid test. Opacification may be quite faint and recognized only by close scrutiny of the x-ray films. The four-day iopanoic acid test is a useful method for identifying bile duct stones. The test is, probably, the best available method for demonstrating bile duct stones in the presence of jaundice. The method is also helpful in identifying gallbladder stones in problem cases.
Salzman E, Spurck RP, Kier LC, Watkins DH. OPACIFYING GALLSTONES. JAMA. 1959;169(4):334–338. doi:10.1001/jama.1959.03000210028007
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