The sensitivity of 270 strains of bacteria isolated from 264 patients with external eye infections was tested against novobiocin. There were 136 strains of coagulase negative staphylococci, all of which were sensitive to novobiocin; 100% sensitivity was likewise found in 89 strains of coagulase positive staphylococci, 5 strains of diplococcus pneumoniae, and 15 strains of alpha and beta hemolytic streptococci. Varied results were obtained with other organisms, and 13 strains of Pseudomonas aeruginosa were found uniformly resistant. Thirty patients with various clinical types of external ocular infection were treated with an ointment containing 1 % novobiocin every three hours during the day. Clinical cure resulted in 28; in the two unsuccessful cases the infection was ascribed to either a fungus or a virus. The effectiveness of novobiocin was demonstrated, but the authors advise limiting its use to the more serious eye infections.
Suie T, Sroufe SA, Havener WH. OPHTHALMIC USE OF NOVOBIOCIN. JAMA. 1959;169(6):580–582. doi:10.1001/jama.1959.03000230036008
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