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A physician, aged 63 in 1958, consulted one of us (P. D. W.) in November, 1933, because of symptoms of fatigue and a daily precordial ache dating back six months. There was no angina pectoris on effort. Nitroglycerin had no effect on this ache. He had always been well and active and had suffered only mild diphtheria as a child, tonsillitis with tonsillectomy in 1918, mild influenza in 1922, and appendicitis with operation in 1925. He had noted extrasystoles for a few weeks in 1929. His habits included moderate use of tobacco (20 cigarettes a day) and of alcohol and coffee, and overwork with few holidays.
The family history at that time revealed that his mother and one brother were living and well; one brother had died of rheumatic heart disease at 10 years of age and a sister of heart disease at the age of 4. The father died
White PD, Griffith GC. INVALIDISM ABOLISHED BY TRANSFORMING PAROXYSMAL TO PERMANENT ATRIAL FIBRILLATION. JAMA. 1959;169(6):596–597. doi:10.1001/jama.1959.73000230006011c
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