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February 7, 1959


Author Affiliations

3347 Government St. Baton Rouge 6, La.

JAMA. 1959;169(6):640. doi:10.1001/jama.1959.03000230096024

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To the Editor:—  The following is an addendum to my article on page 559 of this issue of The Journal, After a communication from the Department of Clinical Investigation of Parke Davis & Company received on Jan. 26, a review of the relationship of chloramphenicol therapy to the cases reported in my article was undertaken; 22 of the 30 patients received on Jan. 26, a review of the relationship of the 12 who died 10 were given chloramphenicol orally, intramuscularly, or intravenously in doses ranging from 50 to 313 mg. per kilogram per day. Most of these infants were given about 150 mg. per kilogram per day. It was pointed out by the communication from Parke Davis & Company that large doses of chloramphenicol, when given to premature and newborn infants, produced the following findings, and sometimes death:

  1. Abdominal distention within two or three days of institution of therapy.

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