In the theory of hemolytic transfusion reactions and of hemolytic disease in the fetus and the newborn, the Rh0 factor holds a special position. It is the most antigenic of the Rh-Hr blood factors and the usual source of clinical complications. Because of the recent discovery of new antibodies within this system it has become necessary to assume that standard Rh-positive blood contains factors RhA, RhB, Rhc, and others, as well as Rh0. The theory and nomenclature here developed makes it easier to understand the interrelations of these factors and should aid the physician in solving certain puzzling clinical problems. Its predictive value makes it helpful in planning further investigations.
Wiener AS, Unger LJ. Rh FACTORS RELATED TO THE Rho FACTOR AS A SOURCE OF CLINICAL PROBLEMS: DIAGRAMMATIC REPRESENTATION OF THEIR REACTIONS AND PREDICTION OF STILL UNDISCOVERED Rh FACTORS. JAMA. 1959;169(7):696–699. doi:10.1001/jama.1959.03000240034008
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