The effectiveness of D-pantothenyl alcohol in the treatment of paralytic ileus was tested by comparing two groups of 50 patients after abdominal operations. Both groups received the customary postoperative care as seemed indicated by the attending surgeon, but in addition 50 patients received intramuscular injections of 250 mg. of D-pantothenyl alcohol every six hours until normal peristalsis was established, while the remaining 50 received a placebo in the same manner. In the group receiving the drug it was possible to discontinue the use of tubes and of venoclysis sooner than in the other group, but it was debatable whether the actual difference in the average case was of practical importance. The drug was used in 12 additional patients who had profound postoperative intestinal atony, and in each case it appeared to cause resumption of bowel sounds, passage of flatus, and relief from distention. No undesired side-effects were observed.
Frazer JW, Flowe BH, Anlyan WG. D-PANTOTHENYL ALCOHOL IN MANAGEMENT OF PARALYTIC ILEUS. JAMA. 1959;169(10):1047–1051. doi:10.1001/jama.1959.03000270029007
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