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March 7, 1959


JAMA. 1959;169(10):1139. doi:10.1001/jama.1959.03000270121019

The authors of this monograph have imparted a wealth of highly practical information obtained over a 15-year period of firsthand experience with penicillin. The slant of the book is clinical rather than pharmacological. After a brief historical introduction the antimicrobial spectrum of penicillin is discussed. This chapter identifies those areas in which penicillin is of proved value and points out those infections against which it is clearly ineffective and hence not indicated. Practical suggestions are also given for reducing the incidence of hospital-acquired infections due to penicillin-resistant strains of staphylococci. The clinical aspects of the pharmacology and toxicity of penicillin are briefly but competently presented. The chapter on dosage forms contains useful information on the characteristics of the diverse commercial preparations. The remainder of the book is devoted to a discussion of the use of penicillin in specific infections known to respond to its antimicrobial action. Each section is prefaced

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