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March 7, 1959

Acetophenetidin: A Critical Bibliographic Review

JAMA. 1959;169(10):1142-1143. doi:10.1001/jama.1959.03000270124030

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This book presents a critical review of the literature on the well-known analgesic-antipyretic agent acetophenetidin and its major metabolite N-acetyl-p-aminophenol (p-hydroxyacetanilid), to which the nonproprietary names acetaminophen and paracetamol have been applied. The book includes comments by the author as well as abstracts from the literature and from unpublished data. The main text covers the drug's history, chemistry, fate and metabolism in the body, antipyretic and analgesic actions, other therapeutic uses, effects on blood and other tissues, toxicology, tolerance, and habituation, and a summary. The bibliography and a general index appear at the end of the book. In addition to reviewing data pertaining only to acetophenetidin, the literature abstracted also includes studies of its comparative and/or combined action with such other drugs as aminopyrine, antipyrine, allylbarbituric acid, amobarbital, aspirin, salicylamide, and neocinchophen. This monograph should be of special interest and use to pharmacologists and clinical investigators as

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