[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 35.173.234.169. Please contact the publisher to request reinstatement.
Article
March 7, 1959

Acetophenetidin: A Critical Bibliographic Review

JAMA. 1959;169(10):1142-1143. doi:10.1001/jama.1959.03000270124030

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

This book presents a critical review of the literature on the well-known analgesic-antipyretic agent acetophenetidin and its major metabolite N-acetyl-p-aminophenol (p-hydroxyacetanilid), to which the nonproprietary names acetaminophen and paracetamol have been applied. The book includes comments by the author as well as abstracts from the literature and from unpublished data. The main text covers the drug's history, chemistry, fate and metabolism in the body, antipyretic and analgesic actions, other therapeutic uses, effects on blood and other tissues, toxicology, tolerance, and habituation, and a summary. The bibliography and a general index appear at the end of the book. In addition to reviewing data pertaining only to acetophenetidin, the literature abstracted also includes studies of its comparative and/or combined action with such other drugs as aminopyrine, antipyrine, allylbarbituric acid, amobarbital, aspirin, salicylamide, and neocinchophen. This monograph should be of special interest and use to pharmacologists and clinical investigators as

First Page Preview View Large
First page PDF preview
First page PDF preview
×