The possibility that fibrosis of the pancreas might be related in some way to disease of the liver was explored in a study of material from 1,000 consecutive autopsies. Among these, 778 were free from disease of the liver; in the remaining 222 there was either fatty infiltration or cirrhosis or both. Fibrosis of the pancreas was present in 234 cases and absent in 766. There were 156 cases in which fibrosis of the pancreas was present together with involvement of the liver. This indicates a high degree of association between the two conditions.