Syrosingopine, a drug derived from reserpine, was administered orally to 77 ambulant patients for the treatment of essential hypertension. Group 1 consisted of 38 patients not previously treated for hypertension. Group 2 consisted of 34 patients who had been maintained on therapy with reserpine, were changed to therapy with syrosingopine, and were maintained on it for an average of three months. Group 3 consisted of five patients on combination drug therapy who had severe mental depression or other symptoms of intolerance when maintained on therapy with older antihypertensive drugs. In group 1,16 patients (42 % ) responded with a clinically significant fall in mean blood pressure. In group 2 the blood pressure was controlled without side-effects by individual adjustment of dosage. In group 3 the dosage used (3 mg. of syrosingopine per day) maintained the desired antihypertensive effect without nightmares, nasal congestion, or other significant side-effects.
Herrmann GR, Vogelpohl EB, Hejtmancik MR, Wright JC. THERAPY OF HYPERTENSION WITH ORALLY GIVEN SYROSINGOPINE. JAMA. 1959;169(14):1609–1612. doi:10.1001/jama.1959.03000310061013
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