The possibility of using mephentermine sulfate to treat various types of hypotension was studied in three groups of patients. Group 1 consisted of 10 patients who had hypotensive episodes during a rigorous course of treatment for essential hypertension or hypertensive renal disease. Group 2 consisted of 10 patients who had hypotensive episodes related either to diabetes or to cerebral arteriosclerosis. Group 3 consisted of 10 patients with a variety of nonspecific hypotensive syndromes. Measurements of blood pressure, of maximum ventricular excursion by roentgenkymography, of the I-J wave in ballistocardiograms, of blood flow in the finger, and of peripheral vascular resistance showed that mephentermine in the dosages used corrected the hypotension by both central and peripheral action. It was active when given orally, intramuscularly, or intravenously. For the type of hypotension seen in group 2, a daily oral dose of 12.5 mg. after the morning or noonday meal usually sufficed.
Winsor T. MEPHENTERMINE SULFATE FOR TREATMENT OF ARTERIAL HYPOTENSION. JAMA. 1959;169(15):1742–1747. doi:10.1001/jama.1959.03000320044012
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