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Article
April 18, 1959

REMISSION OF LETTERER-SIWE DISEASE AFTER PREDNISONE THERAPYREPORT OF A CASE

JAMA. 1959;169(16):1877-1879. doi:10.1001/jama.1959.73000330002008a
Abstract

The expected course of Letterer-Siwe disease, considered by many a manifestation of reticuloendotheliosis (lymphoma, type not specified), is progressive deterioration and fatal outcome within the second year of the disease. Therefore, any case exhibiting clinical and roentgenographic evidence of remission deserves to be reported so that the therapeutic program can be further evaluated by others. This paper concerns a case in which steady improvement has occurred for a period exceeding two years after the administration of prednisone.

Report of a Case  A boy born July 29, 1954, weighing 8 lb. 13 oz. (4 kg.) at birth, developed without complications during early infancy. At 1 to 2 weeks of age the infant appeared to have a crop of comedones (blackheads) which were brought to the attention of a physician, who told the mother that one of the lesions on the face was a wart, which he "burned off." Subsequently the mother

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