A patient with a severe systemic infection was treated unsuccessfully with penicillin, chloramphenicol, and a third unidentified antibiotic. Salmonella typhi was cultured from blood and feces and was found sensitive to synnematin B. The condition of the patient had become very critical when therapy with synnematin B was begun, and it continued to be critical during the first 48 hours. Thereafter, improvement was rapid. Eleven days after discharge the patient was readmitted with typhoid peritonitis ascribed to rupture of an infected ovarian cyst. From this setback the patient recovered without any antibiotic treatment, and subsequent tests indicate that she is not a carrier. Her son and father-in-law also had mild forms of typhoid; they recovered on treatment with chloramphenicol.
Henderson ND, Garlock FC, Olson BH. TREATMENT OF ACUTE TYPHOID WITH SYNNEMATIN B: REPORT OF A CASE. JAMA. 1959;169(17):1991–1994. doi:10.1001/jama.1959.03000340023006
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: